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Because of these risks, avoid use of opioid cough medications in patients taking benzodiazepines, other CNS depressants, or alcoholsee Drug Interactions 7. Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioids alone.PROMETHAZINE WITH CODEINE ORAL SOLUTION contains 2 medicines, promethazine and codeine.

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The author would like to thank Pya Seidner for her enormous assistance in the preparation of this manuscript. Apfel CC, Cakmakkaya OS, Frings G, et al.Talk with the doctor about the risks and benefits of this medication.

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